Large species differences in the expression of carboxylesterases (CE) have been described,
but the interrelationships of CEs across species are not well characterized. In the current …

Carboxylesterases (EC 3.1. 1.1) comprise a group of serine hydrolases with at least 20
genetically distinct loci in mice. Here, we describe differential display PCR-based cloning of …

This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

The bioavailability of therapeutic agents can be improved by using prodrugs which have
better passive diffusion than the active agents. Intestinal hydrolysis is an important reaction …

▪ Abstract Multiple carboxylesterases (EC 3.1. 1.1) play an important role in the hydrolytic
biotransformation of a vast number of structurally diverse drugs. These enzymes are major …

Hydrolase activity from human liver and small intestine microsomes was compared with that
of recombinant human carboxylesterases, hCE-1 and hCE-2. Although both hCE-1 and hCE …

Carboxylesterases (CESs) located in the intestine play an unique role in the absorption of
many drugs especially ester prodrugs. In order to determine the expression and hydrolyzing …

Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine
esterases responsible for the hydrolysis of ester and amide bonds present in a number of …

Carboxylesterase 5 (CES5)(also called cauxin or CES7) is one of at least five mammalian
CES gene families encoding enzymes of broad substrate specificity and catalyzing …

INTRODUCTION: The effects of buffer and substrate solvent conditions on in vitro activity of
carboxylesterases (CE) have not been previously described. Therefore, it is unknown if the …