Microglial cells participate in brain development and influence neuronal loss and synaptic
maturation. Fractalkine is an important neuronal chemokine whose expression increases …

Microglial cells are the resident macrophages of the central nervous system (CNS). Besides
their classical roles in pathological conditions, these immune cells also dynamically interact …

CX3CR1 is a G protein‐coupled receptor that is expressed exclusively by microglia within
the brain parenchyma. The only known physiological CX3CR1 ligand is the chemokine …

An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …

Neural circuits are constantly monitored and supported by the surrounding microglial cells,
using finely tuned mechanisms which include both direct contact and release of soluble …

Microglia have recently been implicated as key regulators of activity‐dependent plasticity,
where they contribute to the removal of inappropriate or excess synapses. However, the …

Microglia, the resident inflammatory cells of the CNS, are the only CNS cells that express the
fractalkine receptor (CX3CR1). Using three different in vivo models, we show that CX3CR1 …

Previous studies have shown that microglia impact the proliferation and differentiation of
neurons during hippocampal neurogenesis via the fractalkine/CX3 chemokine receptor 1 …

Cx3cr1, the receptor for the chemokine Cx3cl1 (fractalkine), has been implicated in the
progression and severity of Alzheimer's disease-like pathology in mice, but the underlying …

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the
central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is …