Microglia have been implicated in multiple sclerosis (MS) pathogenesis. The fractalkine
receptor CX3CR1 limits the activation of pathogenic microglia and the human polymorphic …

Microglial cells are difficult to track during development because of the lack of specific
reagents for myeloid subpopulations. To further understand how myeloid lineages …

Fractalkine (CX3C chemokine ligand 1, CX3CL1) is an essential chemokine, for regulating
adhesion and chemotaxis through binding to CX3CR1, which plays a critical role in the …

Several cytokines and chemokines are now known to play normal physiological roles in the
brain where they act as key regulators of communication between neurons, glia, and …

Chronic stress is one of the most relevant triggering factors for major depression. Microglial
cells are highly sensitive to stress and, more generally, to environmental challenges …

In the CNS, the chemokine CX3CL1 (fractalkine) is expressed on neurons while its specific
receptor CX3CR1 is expressed on microglia and macrophages. Microglia play an important …

Neuronal fractalkine acts via its receptor, CX3CR1, on microglia to regulate
neuroinflammation. Conflicting results have been reported in studies employing CX3CR1 …

CX3CR1 (fractalkine receptor) is important for sustaining normal microglial activity in the
brain. Lack of CX3CR1 reportedly results in neurotoxic microglial phenotype in disease …

Accumulative evidence indicates that microglial cells influence the normal development of
brain synapses. Yet, the mechanisms by which these immune cells target maturating …

The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine
receptor 1 (CX3CR1) signaling in neurodegenerative disease is an intricate and highly …