The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to
neuron–glia interaction and the regulation of microglial cell activation. Fractalkine is …

Fractalkine (CX3CL1) is an intriguing chemokine that plays a central role in the nervous
system. The expression of CX3CL1 on neurons and of its receptor CX3CR1 on microglia …

Abstract Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that
mediates communication between neurons and microglia. By regulating microglial activity …

An impaired ability to regulate microglia activation by fractalkine (CX3CL1) leads to
microglia chronic sub-activation. How this condition affects outcome after acute brain injury …

Since the initial cloning of fractalkine/CX3CL1, it was proposed that the only known member
of the CX3C or δ subfamily of chemotactic cytokines could play some significant role in the …

Microglia and astrocytes are the major source of cytokines in Alzheimer, s disease (AD).
CX3CR1 is a delta chemokine receptor found in microglia and its neuronal ligand …

Recent in vitro and in vivo studies have shown that the chemokine fractalkine is widely
expressed in the brain and localized principally to neurons. Central nervous system …

Microglia, the primary immune effector cells in the brain, continually monitor the tissue
parenchyma for pathological alterations and become activated in Alzheimer's disease. Loss …

Fractalkine: moving from chemotaxis to neuroprotection | Nature Neuroscience Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Demyelinating disorders of the central nervous system (CNS) occur when myelin and
oligodendrocytes are damaged or lost. Remyelination and regeneration of oligodendrocytes …