In order to understand processes involved in central nervous system inflammatory diseases,
a critical appreciation of mechanisms involved in the control of immune function in the brain …

Homo and heterozygote cx3cr1 mutant mice, which harbor a green fluorescent protein
(EGFP) in their cx3cr1 loci, represent a widely used animal model to study microglia and …

Microglia, the resident immune cells of the brain, perform elaborate surveillance in which
they physically interact with neuronal elements. A novel form of microglia–neuron interaction …

The soluble form of the chemokine fractalkine/CX 3 CL1 regulates microglia activation in the
central nervous system (CNS), ultimately affecting neuronal survival. This study aims to …

During development, newborn interneurons migrate throughout the embryonic brain. Here,
we provide evidence that these interneurons act in a paracrine fashion to regulate …

Blocking the effects of fractalkine therapeutically may regulate microglia cell activation and
provide neuroprotection in the AD brain. A human herpesvirus 8-encoded chemokine …

Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

Background Neuroinflammation is an important secondary mechanism that is a key mediator
of the long-term consequences of neuronal injury that occur in traumatic brain injury (TBI) …

In this study, we investigate the expression of fractalkine (CX3CL1) and the fractalkine
receptor (CX3CR1) in the naive rat and mouse central nervous system (CNS). We determine …

Several neurodegenerative disorders are associated with evidence of inflammation, one
feature of which is increased activation of microglia, the most likely cellular source of …