Abstract Background The fractalkine (CX3CR1) ligand is expressed in astrocytes and
reported to be neuroprotective. When cleaved from the membrane, soluble fractalkine …

Temporal lobe seizures lead to an acute inflammatory response in the brain primarily
characterized by activation of parenchymal microglial cells. Simultaneously, degeneration of …

The abnormal accumulation of amyloid fibrils in the brain is pathognomonic of Alzheimer's
disease. Amyloid fibrils induce significant neuroinflammation characterized by the activation …

Background Microglia are resident mononuclear phagocytes of the brain that become
activated in response to insults including neurodegenerative diseases such as Alzheimer's …

The chemokine CX3CL1/fractalkine is expressed by neurons as a transmembrane-anchored
protein that can be cleaved to yield a soluble isoform. However, the roles for these two types …

Background Interactions between fractalkine (CX 3 CL1) and fractalkine receptor (CX 3
CR1) regulate microglial activation in the CNS. Recent findings indicate that age-associated …

Inflammation during pregnancy can disturb brain development and lead to disorders in the
progeny, including autism spectrum disorder and schizophrenia. However, the mechanism …

Molecular analyses of the chemokine fractalkine and its receptor CX 3 C-R1 in the rat brain
have revealed a striking polarization: fractalkine is expressed constitutively in neurons and …

A recently identified chemokine, fractalkine, is a member of the chemokine gene family,
which consists principally of secreted, proinflammatory molecules. Fractalkine is …

Fractalkine (CX3CL1) to fractalkine receptor (CX3CR1) interactions in the brain are involved
in the modulation of microglial activation. Our recent findings indicate that there is microglial …