The bidirectional communication between neurons and microglia is fundamental for the
proper functioning of the central nervous system (CNS). Chemokines and clusters of …

Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD).
Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been …

Fractalkine, a chemokine anchored to neurons or peripheral endothelial cells, serves as an
adhesion molecule or as a soluble chemoattractant. Fractalkine binds CX3CR1 on microglia …

Fractalkine/CX3CL1 is a neuron-associated chemokine, which modulates microglia-induced
neurotoxicity activating the specific and unique receptor CX3CR1. CX3CL1/CX3CR1 …

The chemokine fractalkine (CX 3 CL1) is constitutively expressed by central neurons,
regulating microglial responses including chemotaxis, activation, and toxicity. Through the …

Reactive microglia are suggested to be involved in neurological disorders, and the
mechanisms underlying microglial activity may provide insights into therapeutic strategies …

Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

The CX3C-chemokine, fractalkine is reportedly to be expressed in the central nervous
system, and up-regulated in certain pathological conditions, such as HIV encephalopathy …

Fractalkine (FKN) is a membrane‐bound chemokine that can be cleaved by proteases such
as ADAM 10, ADAM 17, and cathepsin S to generate soluble fragments. Studies using …

Abstract Background Fractalkine (CX 3 CL1) and its receptor (CX 3 CR1) play an important
role in regulating microglial function. We have previously shown that Cx 3 cr1 deficiency …