Background Microglia play a key role in neuronal circuit and synaptic maturation in the
developing brain. In the healthy adult, however, their role is less clear: microglial …

Leukocyte migration and activation play an important role in immune surveillance and the
pathogenesis of a variety of neurodegenerative disorders, including human …

Background Despite its identification as a key checkpoint regulator of microglial activation in
Alzheimer's disease, the overarching role of CX3CR1 signaling in modulating mechanisms …

Fractalkine is the only known member of the CX3C-chemokine family, and so is its receptor
CX3CR1. Fractalkine, typically is expressed by neurons where it is inserted in the plasma …

Leukocyte trafficking to the central nervous system (CNS), regulated in part by chemokines,
determines severity of the demyelinating diseases multiple sclerosis (MS) and experimental …

Excitotoxicity is a cell death caused by excessive exposure to glutamate (Glu), contributing
to neuronal degeneration in many acute and chronic CNS diseases. We explored the role of …

Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system (CNS). It is associated with local activation of microglia and astroglia, infiltration of …

White matter lesions are common when global cerebral ischemia (GCI) occurs in the elderly,
and cause damage to neurological and psychological functions. Remyelination often fails …

The exact roles of activated microglia and fractalkine (CX3CL1)/fractalkine receptor
(CX3CR1) signaling are not fully understood in brain ischemic injury and the findings …

Oligodendrogenesis occurs during early postnatal development, coincident with
neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning …