Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently
found in aging men. Androgens are essential for the development and differentiated function …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Androgens are essential for the development, growth, and maintenance of the prostate.
They exert their effects via the intracellular androgen receptor (AR), which is a ligand …

The acquisition of an androgen-independent phenotype by prostate cancer cells is presently
a death sentence for patients. In order to have a realistic chance of changing this outcome …

The effectiveness of androgen ablation in the management of advanced prostate cancer is
of limited duration, with the median length of response being only 18–24 months. The …

Prostate cancer is one of the major causes of cancer-related death in the western world.
Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the …

Prostate cancer (PCa) is the leading diagnosed malignancy in men in western countries.
The relationship between androgens and the androgen receptor (AR) has been studied …

OBJECTIVE Knowledge of the molecular and cellular changes that occur during the
transition of hormone‐naïve to castration‐resistant prostate cancer (CRPC) is increasing …

Background: Androgens play an essential role in the development and differentiation of the
prostate gland; their contribution to pathological conditions, such as benign prostatic …

BACKGROUND Endocrine therapy for prostate cancer aims to reduce the levels of
circulating androgen or to inhibit androgen action by blocking the androgen receptor in the …