Prostate cancer is one of the major causes of cancer-related death in the western world.
Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the …

OBJECTIVE Knowledge of the molecular and cellular changes that occur during the
transition of hormone‐naïve to castration‐resistant prostate cancer (CRPC) is increasing …

Background: Androgens play an essential role in the development and differentiation of the
prostate gland; their contribution to pathological conditions, such as benign prostatic …

BACKGROUND Endocrine therapy for prostate cancer aims to reduce the levels of
circulating androgen or to inhibit androgen action by blocking the androgen receptor in the …

The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

Prostate cancer (PCa) is the leading diagnosed malignancy in men in western countries.
The relationship between androgens and the androgen receptor (AR) has been studied …

Residual tissue androgens are consistently detected within the prostate tumors of castrate
individuals and are thought to play a critical role in facilitating the androgen receptor …

The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …

BACKGROUND Various studies have implicated the androgen receptor (AR) in the
progression of androgen‐dependent human prostate cancer cells to androgen‐independent …

This review is triggered by recent developments that offer new explanations for the
mechanism of progression of prostate cancer to androgen independence. Established and …