Due to late onset hypogonadism (LOH), there is an increased usage of testosterone
replacement therapy (TRT) in the aging male population. Since prostate is a target organ for …

Androgens and androgen receptor (AR) signaling are necessary for prostate development
and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The …

Since the effectiveness of androgen deprivation for treatment of advanced prostate cancer
was first demonstrated, prevention strategies and medical therapies for prostate cancer have …

Prostate cancer is the most frequently diagnosed non‐skin cancer and the third leading
cause of cancer mortality in men. In the initial stages, prostate cancer is dependent on …

Prostate carcinoma is the most frequently diagnosed malignancy and the second leading
cause of death as a result of cancer in men in the western countries. Withdrawal of …

Multiple genetic changes are required to produce prostatic cancer cells that can metastasize
and kill the patient (1, 2). The most fundamental consequence of these molecular …

Although prostate cancer is heterogeneous in its etiology and progression, androgen
signaling through the androgen receptor (AR) appears to be involved in all aspects of the …

Although systemic androgen deprivation prolongs life in advanced prostate cancer,
remissions are temporary because patients almost uniformly progress to a state of a …

Since the original observations of Huggins and Hodges that prostate cancers are androgen
dependent, androgen ablation therapy has been the gold standard for the treatment of …

Androgens are important not only for the development and function of the normal prostate
gland, but also for the maintenance of prostate cancer (PCa) cells. The biological function of …