Personalized cancer therapy is likely to be one of the next big advances in our search for a
cure for cancer. To be able to treat people in an individualized manner, researchers need to …

Background Breast cancer (BC) is a complex disease with various subtypes and genetic
alterations that impact DNA repair pathways. Understanding these pathways is essential for …

DNA repair is a vital mechanism in cells that protects against DNA damage caused by
internal and external factors. It involves a network of signaling pathways that monitor and …

The knowledge of specific genetic changes and their biological consequences is critical to
an understanding of the natural history of breast tumors and the development of rational …

DNA damage/repair constitutes several key pathways working in concert to eliminate DNA
lesions and maintain genome stability and integrity. Defective components in DNA damage …

Massively parallel DNA and RNA sequencing approaches have generated data on
thousands of breast cancer genomes. In this review, we consider progress largely from the …

A breast cancer genome is a record of the historic mutagenic activity that has occurred
throughout the development of the tumor. Indeed, every mutation may be informative …

DNA repair pathways can enable tumor cells to survive DNA damage induced by
chemotherapy and thus provide prognostic and/or predictive value. We evaluated Affymetrix …

Signatures of DNA-Repair Deficiencies in Breast Cancer | New England Journal of Medicine
Skip to main content Access provided byUT MD ANDERSON CANCER CENTER The New …

Breast cancer is not a single disease. Genetic array tools can define several subtypes.
Specific biological processes and distinct gene pathways are associated with prognosis and …