The design, synthesis and biological evaluation of the artificial enterobactin analogue EntKL
and several fluorophore-conjugates thereof are described. EntKL provides an attachment …

The design and syntheses of monofunctionalized enterobactin (Ent, l-and d-isomers)
scaffolds where one catecholate moiety of enterobactin houses an alkene, aldehyde, or …

Conspectus Siderophores are secondary metabolites utilized by bacteria to acquire iron
(Fe), an essential transition metal nutrient. Fe levels in the host environment are tightly …

The design, synthesis, and characterization of enterobactin–antibiotic conjugates, hereafter
Ent-Amp/Amx, where the β-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are …

Developing new antibiotics and delivery strategies is of critical importance for treating
infections caused by Gram-negative bacterial pathogens. Hijacking bacterial iron uptake …

Iron is an essential growth factor for bacteria, but although highly abundant in nature, its
bioavailability during infection in the human host or the environment is limited. Therefore …

A solid-phase platform for the precise and sequential synthesis of enterobactin analogues is
described. This chemistry unites the power of solid-phase peptide synthesis with the unique …

Siderophores, such as enterobactin (Ent), are small molecules that can be selectively
imported into bacteria along with iron by cognate transporters. Siderophore conjugates are …

Bacteria often produce siderophores to facilitate iron uptake. One of the most studied
siderophores is enterobactin, the macrolactone trimer of 2, 3-dihydroxybenzoyl-l-serine …

Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …