Background Fibrosis is commonly found in association with cardiac hypertrophy and failure,
but the relation of the connective tissue response to the development of impaired cardiac …

Left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHR) is
accompanied by a structural remodeling of the myocardium that includes myocyte …

An abnormal elevation in collagen concentration or myocardial fibrosis occurs in the
hypertrophied left ventricle of the rat with renovascular hypertension (RHT). The structural …

Objectives: Diastolic dysfunction that determines symptoms and prognosis in patients with
systolic dysfunction causes heart failure even in the absence of systolic dysfunction. Our …

Spontaneously hypertensive rats (SHR) of advanced age exhibit depressed myocardial
contractile function and ventricular fibrosis, as stable compensated hypertrophy progresses …

Background The relative contributions of increases in myocardial collagen, collagen cross-
linking, and the ratio of type I to type III collagen to the stiff myocardium in hypertension were …

Objective Extracellular matrix, particularly type I fibrillar collagen, provides tensile strength
that allows cardiac muscle to perform systolic and diastolic functions. Collagen is induced …

This study tested the hypothesis that with hypertrophy, the proportion, distribution, and
structural alignment of fibrillar collagen are important determinants of myocardial stiffness …

Objective: In left ventricular hypertrophy (LVH) due to systemic hypertension, myocardial
fibrosis is an important determinant of pathologic hypertrophy. Therefore, it is most relevant …

Objective: To assess whether the variable impact of quantitative changes in myocardial
collagen on left ventricular (LV) diastolic myocardial stiffness (myocardial k) and remodelling …