The microbes that inhabit the human body are integral to human health and disease: from
inflammatory bowel disease to allergy, metabolic syndrome to autism. Due to its high …

Applying synthetic biology to engineer gut-resident microbes provides new avenues to
investigate microbe-host interactions, perform diagnostics, and deliver therapeutics. Here …

Engineering commensal organisms for challenging applications, such as modulating the gut
ecosystem, is hampered by the lack of genetic parts. Here, we describe promoters, ribosome …

The gut microbiome is increasingly understood to play a key role in human health.
Commensal gut microbes influence immunity, pathogen colonization, digestion, and brain …

Techniques by which to genetically manipulate members of the microbiota enable both the
evaluation of host-microbe interactions and an avenue by which to monitor and modulate …

Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease
detection and management but is impeded by access to the remote and complex …

Studies of the gut microbiota have dramatically increased in recent years as the importance
of this microbial ecosystem to human health and disease is better appreciated. The …

A Toolbox for Microbiome Engineering: Cell Systems Skip to Main Content Advertisement Cell
Systems This journal offers authors two options (open access or subscription) to publish …

Microbial communities and their collective genomes form the gut microbiome, of which
bacteria are the major contributor. Through their secreted metabolites, bacteria interact with …

Hundreds of microbiota genes are associated with host biology/disease. Unraveling the
causal contribution of a microbiota gene to host biology remains difficult because many are …