METHODS Animals. The construction of 3xTg-AD mouse harboring APP Swe, PS1M146V,
and tauP301L human transgenes is well documented along with the pathologic …

OBJECTIVE Both the consumption of high-fat diets and exercise are known to produce
alterations in metabolism and behavior. This study focuses on the effects of a change to a …

We aimed to investigate the effects of two physical exercise models, voluntary physical
activity (VPA) and endurance training (ET) as preventive and therapeutic strategies …

High-fat diets rapidly cause weight gain and glucose intolerance. We sought to determine
whether these changes could be mitigated with prior exercise training. Male C57BL/6J mice …

Regular physical exercise has emerged, together with dietary restriction, as an effective
intervention in delaying degenerative diseases and augmenting life span in rodents. The …

Adipose tissue inflammation causes metabolic disturbances, including insulin resistance
and hepatic steatosis. Exercise training (EX) may decrease adipose tissue inflammation …

Exercise mitigates obesity-associated pathologies; however, there is controversy regarding
optimal exercise interventions. Autophagy, is known to decrease during obesity and is an …

Physical activity is an efficient strategy to delay development of obesity and insulin
resistance, and thus the progression of obesity/diabetes-related cardiomyopathy. In support …

Objective: Increased dietary fat intake is a precipitating factor for the development of obesity
and associated metabolic disturbances. Physically active individuals generally have a …

In a mouse model for juvenile obesity, we investigated how the age of onset of voluntary
exercise affects factors of the metabolic syndrome. One exercise group had access to …