Current status and perspectives of regulatory T cell-based therapy
G Qu, J Chen, Y Li, Y Yuan, R Liang, B Li - Journal of Genetics and …, 2022 - Elsevier
Abstract The CD4+ FOXP3+ regulatory T (Treg) cells are essential for maintaining immune
homeostasis in healthy individuals. Results from clinical trials of Treg cell-based therapies in …
homeostasis in healthy individuals. Results from clinical trials of Treg cell-based therapies in …
CD4+Foxp3+ regulatory T cell therapy in transplantation
Q Tang, JA Bluestone, SM Kang - Journal of molecular cell …, 2012 - academic.oup.com
Regulatory T cells (Tregs) are long-lived cells that suppress immune responses in vivo in a
dominant and antigen-specific manner. Therefore, therapeutic application of Tregs to control …
dominant and antigen-specific manner. Therefore, therapeutic application of Tregs to control …
Harnessing advances in T regulatory cell biology for cellular therapy in transplantation
Cellular therapy with CD4+FOXP3+ T regulatory (Treg) cells is a promising strategy to
induce tolerance after solidorgan transplantation or prevent graft-versus-host disease after …
induce tolerance after solidorgan transplantation or prevent graft-versus-host disease after …
[HTML][HTML] Cell-based therapies with T regulatory cells
M Gliwiński, D Iwaszkiewicz-Grześ, P Trzonkowski - BioDrugs, 2017 - Springer
Abstract CD4+ CD25 high FoxP3+ T regulatory cells (Tregs) are immunodominant
suppressors in the immune system. Tregs use various mechanisms to control immune …
suppressors in the immune system. Tregs use various mechanisms to control immune …
Treg cell therapy: How cell heterogeneity can make the difference
G Giganti, M Atif, Y Mohseni… - European Journal of …, 2021 - Wiley Online Library
Abstract CD4+ CD25highCD127low/− FOXP3+ T regulatory cells are responsible for
maintaining immune tolerance and controlling excessive immune responses. Treg cell use …
maintaining immune tolerance and controlling excessive immune responses. Treg cell use …
[HTML][HTML] Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective
L Amini, J Kaeda, E Fritsche, A Roemhild… - Frontiers in Cell and …, 2023 - frontiersin.org
Rejection of solid organ transplant and graft versus host disease (GvHD) continue to be
challenging in post transplantation management. The introduction of calcineurin inhibitors …
challenging in post transplantation management. The introduction of calcineurin inhibitors …
[HTML][HTML] Tregs in transplantation tolerance: role and therapeutic potential
CD4+ Foxp3+ regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and
they play a role in cancer and transplantation settings by restraining immune responses. In …
they play a role in cancer and transplantation settings by restraining immune responses. In …
Treg cell-based therapies: challenges and perspectives
C Raffin, LT Vo, JA Bluestone - Nature Reviews Immunology, 2020 - nature.com
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
[HTML][HTML] Opportunities for Treg cell therapy for the treatment of human disease
JA Bluestone, BS McKenzie, J Beilke… - Frontiers in …, 2023 - frontiersin.org
Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …
Regulatory T cells in transplantation: what we know and what we do not know
Current immunosuppressive regimens suppress alloimmunity by nonspecifically targeting T-
cell proliferation, differentiation, and activation. In doing so, they have been effective in …
cell proliferation, differentiation, and activation. In doing so, they have been effective in …