Continuous but not pulsed low-dose fetal betamethasone exposures extend the durability of antenatal steroid therapy

T Takahashi, Y Takahashi, EL Fee… - … of Physiology-Lung …, 2022 - journals.physiology.org
Antenatal steroid (ANS) therapy is the standard care for women at imminent risk of preterm
labor. Despite extensive and long-standing use, 40%–50% of babies exposed antenatally to …

The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation

MW Kemp, M Saito, AF Schmidt, H Usuda… - American journal of …, 2020 - Elsevier
Background Antenatal corticosteroids (ACS) are the standard of care for maturing the fetal
lung and improving outcomes for preterm infants. Antenatal corticosteroid dosing remains …

Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of …

T Takahashi, M Saito, AF Schmidt, H Usuda… - American journal of …, 2020 - Elsevier
Background Administration of antenatal steroids is standard of care for women assessed to
be at imminent risk of preterm delivery. There is a marked variation in antenatal steroid …

Effect of antenatal corticosteroid treatment on lung function in full-term newborn infants

O Hjalmarson, KL Sandberg - Neonatology, 2011 - karger.com
Background: Antenatal treatment of pregnant women with corticosteroids in order to
stimulate surfactant production has been shown to be effective. However, lung structure is …

[HTML][HTML] Antenatal Corticosteroids: Extending the Practice for Late-Preterm and Scheduled Early-Term Deliveries?

ZT Htun, JC Hairston, C Gyamfi-Bannerman, J Marasch… - Children, 2021 - mdpi.com
Respiratory distress in late-preterm and early term infants generally may warrant admission
to a special care nursery or an intensive care unit. In particular, respiratory distress …

Antenatal corticosteroids for fetal lung maturity-too much of a good thing?

L Hrabalkova, T Takahashi, MW Kemp… - Current …, 2019 - ingentaconnect.com
Background: Between 5-15% of babies are born prematurely worldwide, with preterm birth
defined as delivery before 37 completed weeks of pregnancy (term is at 40 weeks of …

One percent of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus

EL Fee, T Takahashi, Y Takahashi… - … of Physiology-Lung …, 2022 - journals.physiology.org
Antenatal steroids (ANSs) are routinely administered to women judged to be at imminent risk
of preterm delivery. Their principal benefit is precocious functional maturation of the preterm …

Dose-response effects of betamethasone on maturation of the fetal sheep lung

M Loehle, M Schwab, S Kadner, KM Maner… - American journal of …, 2010 - Elsevier
OBJECTIVE: Glucocorticoid administration to women in preterm labor improves neonatal
mortality and morbidity. Fetal exposure to glucocorticoid levels higher than those …

[HTML][HTML] Antenatal corticosteroid administration for foetal lung maturation

K Wynne, C Rowe, M Delbridge, B Watkins… - …, 2020 - ncbi.nlm.nih.gov
Antenatal corticosteroids are an essential component in the management of women at risk
for preterm labour. They promote lung maturation and reduce the risk of other preterm …

Antenatal corticosteroid treatment: factors other than lung maturation

K Haram, JH Mortensen, EF Magann… - The Journal of Maternal …, 2017 - Taylor & Francis
Antenatal corticosteroid (CS) therapy improves both fetal lung mechanism and gas
exchange due to accelerated morphologic development of type one and two pneumocytes …