T cell signalling induced by bacterial superantigens
C Bueno, G Criado, JK McCormick… - Superantigens and …, 2007 - karger.com
Bacterial superantigens (SAgs) constitute a large family of bacterial toxins that share the
capacity to induce massive activation of the human immune system. Such a feature is based …
capacity to induce massive activation of the human immune system. Such a feature is based …
Novel insights into the immune response to bacterial T cell superantigens
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …
The T cell receptor β-chain second complementarity determining region loop (CDR2β) governs T cell activation and Vβ specificity by bacterial superantigens
AKMN Rahman, DA Bonsor, CA Herfst, F Pollard… - Journal of Biological …, 2011 - ASBMB
Superantigens (SAgs) are microbial toxins defined by their ability to activate T lymphocytes
in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing …
in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing …
T-cell activation or tolerization: the Yin and Yang of bacterial superantigens
A Sähr, S Förmer, D Hildebrand, K Heeg - Frontiers in microbiology, 2015 - frontiersin.org
Bacterial superantigens (SAg) are exotoxins from pathogens which interact with innate and
adaptive immune cells. The paradox that SAgs cause activation and inactivation/anergy of T …
adaptive immune cells. The paradox that SAgs cause activation and inactivation/anergy of T …
Superantigen bacterial toxins: state of the art
H Müller-Alouf, C Carnoy, M Simonet, JE Alouf - Toxicon, 2001 - Elsevier
Sup/erantigens (SAgs) are viral and bacterial proteins exhibiting a highly potent polyclonal
lymphocyte-proliferating activity for CD4+, CD8+ and sometimes γδ+ T cells of human and …
lymphocyte-proliferating activity for CD4+, CD8+ and sometimes γδ+ T cells of human and …
Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM
PM Lavoie, J Thibodeau, I Cloutier… - Proceedings of the …, 1997 - National Acad Sciences
Bacterial superantigens (SAgs) bind to major histocompatibility complex (MHC) class II
molecules and activate T cells in a Vβ-restricted fashion. We recently identified subsets of …
molecules and activate T cells in a Vβ-restricted fashion. We recently identified subsets of …
A novel loop domain in superantigens extends their T cell receptor recognition site
Superantigens (SAGs) interact with host immune receptors to induce a massive release of
inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can …
inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can …
[PDF][PDF] Bacterial superantigens and superantigen-like toxins
The term superantigen (SAg) was coined in 1989 in the research group of Philippa Marrack
and John Kappler and describes a group of proteins with extremely high potency to …
and John Kappler and describes a group of proteins with extremely high potency to …
Molecular requirements for MHC class II α-chain engagement and allelic discrimination by the bacterial superantigen streptococcal pyrogenic exotoxin C
Superantigens (SAgs) are microbial toxins that bind to both TCR β-chain variable domains
(Vβs) and MHC class II molecules, resulting in the activation of T cells in a Vβ-specific …
(Vβs) and MHC class II molecules, resulting in the activation of T cells in a Vβ-specific …
The TCR Vβ signature of bacterial superantigens spreads with stimulus strength
Superantigens (Sags) induce large-scale stimulation of T lymphocytes by a mechanism
distinct from conventional antigen presentation, involving direct MHC binding and …
distinct from conventional antigen presentation, involving direct MHC binding and …