Pharmacokinetics and Pharmacodynamics of Repository Corticotropin Injection Compared With Synthetic ACTH1‐24 Depot and Methylprednisolone in Healthy …
N Poola, B Due, D Wright, LR Brooks… - … Pharmacology in Drug …, 2022 - Wiley Online Library
Repository corticotropin injection (RCI; Acthar Gel) is a naturally sourced complex mixture of
adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. This phase 1 …
adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. This phase 1 …
Comparison of Steroidogenic Exposure Following the Administration of Repository Corticotropin Injection With a Synthetic ACTH1‐24 Depot and Methylprednisolone …
X Wang, L Pham, N Poola, LR Brooks… - … Pharmacology in Drug …, 2021 - Wiley Online Library
The pharmacokinetics (PK) and pharmacodynamics (PD) of clinically relevant doses of
repository corticotropin injection (Acthar Gel) and synthetic ACTH1‐24 depot have not been …
repository corticotropin injection (Acthar Gel) and synthetic ACTH1‐24 depot have not been …
Pharmacodynamics and tolerability of repository corticotropin injection in healthy human subjects: a comparison with intravenous methylprednisolone
R Lal, S Bell, R Challenger, V Hammock… - The Journal of …, 2016 - Wiley Online Library
Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and
intravenous methylprednisolone (IVMP) are used to treat inflammatory conditions such as …
intravenous methylprednisolone (IVMP) are used to treat inflammatory conditions such as …
Adrenocortical response profiles to corticotrophin-releasing hormone and adrenocorticotrophin challenge in the chronically catheterized adult guinea-pig
L Liu, SG Matthews - Experimental physiology, 1999 - cambridge.org
The guinea-pig has been used extensively to investigate adrenal steroidogenesis. However,
very little is known about adrenocortical responses to corticotrophin-releasing hormone …
very little is known about adrenocortical responses to corticotrophin-releasing hormone …
Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel
AS Bomback, JA Tumlin, J Baranski… - Drug design …, 2011 - Taylor & Francis
Purpose A synthetic adrenocorticotropin (ACTH) analog has shown efficacy in Europe as
primary and secondary therapy for nephrotic syndrome, but there is no published …
primary and secondary therapy for nephrotic syndrome, but there is no published …
Diagnostic Study of a Synthetic Human Corticotropin-Releasing Hormone (hCRH) in Healthy Adult Males Its Plasma Pharmacokinetics and the Effects on the Urinary …
K TANAKA, M NAGATA, S ITOH, M KUMAGAE… - Endocrine …, 1993 - jstage.jst.go.jp
The pharmacokinetics, responses of plasma ACTH and cortisol, urinary excretion of steroid
hormones, and safety of MCI-028, a synthetic human corticotropin-releasing hormone …
hormones, and safety of MCI-028, a synthetic human corticotropin-releasing hormone …
Dose-response relationships between plasma adrenocorticotropin (ACTH), cortisol, aldosterone, and 18-hydroxycorticosterone after injection of ACTH-(1–39) or …
W Oelkers, T Boelke, V Bähr, P Exner… - The Journal of …, 1988 - academic.oup.com
The effects of sc injections (at 1500 h) of increasing amounts of synthetic human ACTH-(l–
39)(1.25–30 μ g) on plasma ACTH, cortisol, aldosterone, and 18-hydroxycorticosterone …
39)(1.25–30 μ g) on plasma ACTH, cortisol, aldosterone, and 18-hydroxycorticosterone …
[HTML][HTML] Hp Acthar gel and cosyntropin review: clinical and financial implications
J Gettig, JP Cummings… - Pharmacy and …, 2009 - ncbi.nlm.nih.gov
HP Acthar Gel Repository Injection (Questcor Pharmaceuticals) is a 39-amino-acid peptide
natural form of adrenocorticotropic hormone (ACTH). It works by stimulating the adrenal …
natural form of adrenocorticotropic hormone (ACTH). It works by stimulating the adrenal …
Endogenous ACTH concentration-dependent drive of pulsatile cortisol secretion in the human
DM Keenan, F Roelfsema… - American Journal of …, 2004 - journals.physiology.org
According to current regulatory concepts, pulsatile ACTH concentrations (CON) stimulate
time-lagged cortisol secretion rates (SEC) via an implicit CON-SEC dose-response …
time-lagged cortisol secretion rates (SEC) via an implicit CON-SEC dose-response …
Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study
G Johannsson, R Bergthorsdottir… - European Journal of …, 2009 - academic.oup.com
Background Endogenous plasma cortisol levels have a well-defined circadian rhythm. The
aim of this project is to develop a once daily oral dual-release formulation for cortisol …
aim of this project is to develop a once daily oral dual-release formulation for cortisol …