Background Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate
cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate …

Background Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2,
early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) …

Study Type–Diagnostic (validating cohort) Level of Evidence 1b What's known on the
subject? and What does the study add? Scientists have found a number of genetic factors …

Background: Men with a BRCA2 mutation face an increased risk of prostate cancer. These
cancers tend to have an aggressive nature and it has not yet been demonstrated that regular …

Background BRCA1 and BRCA2 mutations have been associated with prostate cancer
(PCa) risk but a wide range of risk estimates have been reported that are based on …

Background: Prostate cancer (PrCa) is one of the most common cancers affecting men but
its aetiology is poorly understood. Family history of PrCa, particularly at a young age, is a …

There is a high and rising prevalence of prostate cancer (PRCA) within the male population
of the United Kingdom. Although the relative risk of PRCA is higher in male BRCA2 and …

Background: A family history of prostate cancer (PrCa) is a strong risk factor for the disease,
indicating that inherited factors are important in this disease. We previously estimated that …

Purpose: Increased prostate cancer risk has been reported for BRCA mutation carriers, but
BRCA-associated clinicopathologic features have not been clearly defined. Experimental …

Background A prior meta‐analysis found no association between BRCA1 mutation and
prostate cancer (PCa). Subsequent BRCA2 mutation studies have shown an association …