Background Standard dosage regimens of quinine formulated for adult patients with
uncomplicated and complicated malaria have been applied for clinical uses in children …

Objectives Oral quinine is used for the treatment of uncomplicated malaria during
pregnancy, but few pharmacokinetic data are available for this population. Previous studies …

Objectives: The study was conducted in New Halfa teaching hospital, eastern Sudan to
investigate the pharmacokinetics of quinine in pregnant Sudanese women. Methods …

Background The varied disposition of the antimalarial quinine partly explains its poor
tolerance and toxicity in humans. Objective Using a population approach, the disposition of …

Background Both malnutrition and malaria affect drug disposition and are frequent among
children in the tropics. We assessed their respective influence on quinine distribution …

The relationships between the pharmacokinetic properties of quinine during a 7-day
treatment course and the therapeutic response were studied in 30 adult patients with …

The aim of the present study was to assess the pharmacokinetics and the efficacy of a
shorter than usual 5-day quinine treatment given orally to children in Cameroon with malaria …

We present the first population pharmacokinetic analysis of quinine in patients with
Plasmodium falciparum malaria. Ghanaian children (n= 120; aged 12 months to 10 years) …

Heading Abstract Objective. Quinine is an important antimalarial drug that is metabolised
mainly by the hepatic mixed-function microsomal enzyme cytochrome P 450. Cigarette …

Chemotherapy remains the mainstay of malaria management. Most malaria endemic
countries have national recommendations for first line therapy (treatment of uncomplicated …