Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease

S Lehéricy, ÉC Hirsch, P Cervera‐Piérot… - Journal of …, 1993 - Wiley Online Library
Cholinergic neurons were studied by immunohistochemistry, with an antiserum against
choline acetyltransferase (ChAT), in the basal forebrain (Ch1 to Ch4) of four patients with …

Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls

T Nagai, PL McGeer, JH Peng, EG McGeer… - Neuroscience …, 1983 - Elsevier
Choline acetyltransferase (ChAT)-containing neuronal structures of the basal forebrain were
studied by ChAT immunohistochemistry in the brains of persons dying with Alzheimer's …

Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease

C Geula, N Nagykery, A Nicholas… - … of Neuropathology & …, 2008 - academic.oup.com
A large body of evidence indicates that basal forebrain cholinergic neurons are selectively
vulnerable to degeneration early in Alzheimer disease (AD). Recent studies, however …

Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease

C Geula, MM Mesulam - Cerebral cortex, 1996 - academic.oup.com
The loss of cortical cholinergic fibers in Alzheimer's disease was investigated using choline
acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Within …

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for …

RCA Pearson, MV Sofroniew, AC Cuello, TPS Powell… - Brain research, 1983 - Elsevier
Immunohistochemically identified cholinergic neurons in the basal nucleus of Meynert in a
brain with SDAT have been compared with those in two age-and sex-matched normal …

Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data

KJ Reinikainen, PJ Riekkinen, L Paljärvi… - Neurochemical …, 1988 - Springer
Cholinesterase (ChE) activity was measured as a possible marker of cholinergic
neurotransmission of the brain in CSF of 93 patients with probable Alzheimer's …

Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease

JH Xuereb, EK Perry, JM Candy, JR Bonham… - Journal of the …, 1990 - Elsevier
Loss of cholinergic cells in the basal forebrain is associated with commensurate reductions
in cortical acetylcholine-related enzyme activities in both Alzheimer's disease (AD) and …

Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment …

ML Gilmor, JD Erickson, H Varoqui… - Journal of …, 1999 - Wiley Online Library
Immunocytochemistry for choline acetyltransferase (ChAT) and the vesicular acetylcholine
transporter (VAChT) was used to examine the expression of these linked cholinergic …

Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease

RPA Gaykema, C Nyakas, E Horvath, LB Hersh… - Neurobiology of …, 1992 - Elsevier
—Innervation density and morphological aberrations of cholinergic fibers were studied with
choline acetyltransferase (ChAT) immunocytochemistry and acetylcholinesterase (AChE) …

The fate of the brain cholinergic neurons in neurodegenerative diseases

G Pepeu, MG Giovannini - Brain Research, 2017 - Elsevier
The aims of this review are: 1) to describe which cholinergic neurons are affected in brain
neurodegenerative diseases leading to dementia; 2) to discuss the possible causes of the …