Down syndrome (DS) is the most prevalent cause of intellectual disability (ID). Individuals
with DS show a variety of cognitive deficits, most notably in hippocampal learning and …

Down syndrome (DS) is caused by the triplication of human chromosome 21 (HSA21) and is
the most common genetic cause of intellectual disability, with individuals having deficits in …

Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome
(DS) and Alzheimer's disease (AD). Current therapeutics have been unsuccessful in slowing …

We elucidated the molecular fingerprint of vulnerable excitatory neurons within select
cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and …

Down syndrome (DS) is the primary genetic cause of intellectual disability (ID), which is due
to the triplication of human chromosome 21 (HSA21). In addition to ID, HSA21 trisomy …

Individuals with Down syndrome (DS) exhibit intellectual disability and develop Alzheimer's
disease-like neuropathology during the third decade of life. The Ts65Dn mouse model of DS …

Down syndrome (DS) is a genetic disorder caused by triplication of human chromosome 21.
In addition to intellectual disability, DS is defined by a premature aging phenotype and …

Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome
(DS) and Alzheimer's disease (AD). Current therapeutics in these disorders have been …

Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe
memory circuit, are selectively vulnerable during the progression of Alzheimer's disease …

Background: Individuals with Down syndrome (DS) have intellectual disability and develop
Alzheimer's disease (AD) pathology during midlife, particularly in the hippocampal …