With the emergence of the histone code as a key determinant in the regulation of gene
expression, it has been important to develop tools that can not only identify the types and …

Electrospray ionization mass spectrometry, a leading method for the quantification of
biomolecules, is useful for the analysis of posttranslational modifications of proteins. Here …

Histone acetylation and methylation play a critical role in transcription and gene regulation.
Identification of sites of lysine acetylation and methylation in histones or other proteins by …

Histone acetylation is involved in gene regulation and, most importantly, aberrant regulation
of histone acetylation is correlated with major human diseases. Although many lysine …

The acetylation isoforms of histone H4 from butyrate-treated HeLa cells were separated by C
4 reverse-phase high pressure liquid chromatography and by polyacrylamide gel …

The in vitro deuteroacetylation of histones obtained from biological sources has been used
previously in bottom-up mass spectrometry analyses to quantitate the percent of …

Lysine acetylation is an important posttranslational modification (PTM) that regulates the
function of proteins by affecting their localization, stability, binding, and enzymatic activity …

Lysine acetylation is a common protein posttranslational modification that regulates a variety
of biological processes. A major bottleneck to fully understanding the functional aspects of …

Histone acetylation, methylation, and phosphorylation occur predominantly in the
unstructured N‐terminal domains or histone “tails”. These modifications and others comprise …

The acetylation of proteins at specific lysine residues by acetyltransferase enzymes has
emerged as a posttranslational modification of high biological impact. Although lysine …