In eukaryotes, the conjugation of the ubiquitin-like protein NEDD8 onto protein targets is an
important post-translational modification. The best understood neddylation targets are the …

The evolutionarily conserved 8-kD protein NEDD8 (NEURAL PRECURSOR CELL
EXPRESSED, DEVELOPMENTALLY DOWN-REGULATED8) belongs to the family of …

Highlights•NEDD8 promotes the stability and function of Cullin-RING E3 ligases.•COP9
signalosome deneddylates Cullins and destabilizes E3 ligase complexes.•CAND1 serves as …

Neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8) is a ubiquitin-
like modifier, which forms covalent conjugates on lysines of its substrates. This post …

NEDD8, in plants and yeasts also known as RELATED TO UBIQUITIN (RUB), is an
evolutionarily conserved 76 amino acid protein highly related to ubiquitin. Like ubiquitin …

Neddylation is the post-translational protein modification most closely related to
ubiquitination. Whereas the ubiquitin-like protein NEDD8 is well studied for its role in …

NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

The conjugation of the ubiquitin-like modifier NEURAL PRECURSOR CELL-EXPRESSED
DEVELOPMENTALLY DOWN-REGULATED PROTEIN8/RELATED TO UBIQUITIN1 …

Covalent modification of cullins by the ubiquitin-like protein NEDD8 (neddylation) regulates
protein ubiquitination by promoting the assembly of cullin-RING ligase E3 complexes. Like …

The ubiquitin-like molecule NEDD8 controls several biological processes and is a promising
target for therapeutic intervention. NEDDylation occurs through specific NEDD8 enzymes …