Deficiency in DNA damage response (DDR) genes leads to impaired DNA repair functions
that will induce genomic instability and facilitate cancer development. However, alterations …

DNA damage response and repair (DDR) genes play a central role in the life of actively
replicating cells, cooperating to maintenance of genomic integrity. However, exogenous or …

Genomic instability remains an enabling feature of cancer and promotes malignant
transformation. Alterations of DNA damage response (DDR) pathways allow genomic …

DNA damage repair (DDR) pathways play an essential role in maintaining genomic integrity.
DDR dysfunction leads to accumulated DNA damage, predisposition to cancer, and high …

As our understanding of the mechanisms of cancer treatment has increased, a growing
number of studies demonstrate pathways through which DNA damage repair (DDR) affects …

The DNA damage response (DDR) is a complex set of downstream pathways triggered in
response to DNA damage to maintain genomic stability. Many tumours exhibit mutations …

Simple Summary DNA repair pathways play a crucial role in maintaining the stability of a
cell's genetic material. When these pathways are defective, it can lead to genomic instability …

The DNA damage response (DDR) fulfils essential roles to preserve genome integrity.
Targeting the DDR in tumors has had remarkable success over the last decade, exemplified …

Cells are exposed to multiple endogenous and exogenous stresses daily, some of which
can induce DNA damage, a major source of genomic instability. To deal with damaged DNA …

The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …