Background: Type II diabetes (T2D)-induced cardiomyocyte hypertrophy is closely linked to
the impairment of mitochondrial function. Berberine has been shown to be a promising effect …

Berberine has been verified to protect cardiac function in patients with heart failure (HF).
However, the mechanism (s) involved in berberine-mediated cardioprotective effects has not …

Berberine (BBR) is routinely prescribed in many Asian countries to treat diarrhea. Evidence
from both animal and clinical investigations suggests that BBR exerts diverse …

Abstract Ischemia/reperfusion (I/R)-induced autophagy increases the severity of
cardiomyocyte injury. The aim of this study was to investigate the effects of berberine, a …

Berberine, an isoquinoline alkaloid originally isolated from the Chinese herb
Coptischinensis, has been shown to display a wide range of pharmacological effects. The …

Tissue damage in diabetes is at least partly due to elevated reactive oxygen species
production by the mitochondrial respiratory chain during hyperglycemia. Sustained …

Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present
study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia …

Berberine (BBR) has a variety of pharmacological activities and is widely used in Asian
countries. However, the clinical application of BBR still lacks scientific basis, what protective …

Diabetes mellitus is considered to be a major risk factor for cardiovascular disease, the most
common cause of death in diabetes. However, therapeutic strategies for myocardial …

Cerebral ischemia/reperfusion (I/R) is a lethal and disabling disease. Studies have
suggested that hyperglycemia is a risk factor for cerebral I/R. Baicalin is a natural bioactive …