Highlights•There is an emerging need for new therapies for rare diseases in a shorter time
frame.•Drug repurposing could arise from serendipitous observations or exploiting side …

Repurposing drugs requires finding novel therapeutic indications compared to the ones for
which they were already approved. This is an increasingly utilized strategy for finding novel …

Highlights•Drug repurposing gained momentum in the recent past.•Drug repurposing is a
promising strategy for rare disease drug discovery.•Drug repurposing resulted in fruitful …

Because of the high risk, substantial cost and slow pace of new drug discovery and
development, drug repurposing (also called repositioning, redirecting, reprofiling) is …

Drug repurposing has been proposed as a strategy to develop new therapies that has fewer
risks, lower costs and shorter timelines than developing completely new drugs. However, the …

Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …

Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …

Drug repurposing (also known as drug repositioning, drug reprofiling, indication expansion
or indication shift) involves establishing new medical uses for already known drugs …

While nearly 8000 rare diseases have been identified, only 5 percent have licensed
treatments. As most of these diseases are life threatening, it underscores the urgent need for …

Currently, there are about 7000 identified rare diseases, together affecting 10% of the
population. However, fewer than 6% of all rare diseases have an approved treatment option …