Food intake and energy expenditure are determinants of metabolic phenotype and are
regulated by the CNS. Although humans have a well-balanced homeostatic feedback loop …

Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …

The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …

Obesity and type 2 diabetes mellitus (T2DM)—disorders of energy homeostasis and glucose
homeostasis, respectively—are tightly linked and the incidences of both conditions are …

With the bleak outlook that 75% of Americans will be overweight or obese in 10 years, it is
essential to find efficient help very soon. Knowledge of the powerful and complex neural …

The CNS regulates body weight; however, we still lack a clear understanding of what drives
decisions about when, how much and what to eat. A vast array of peripheral signals …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

Early lesion studies and subsequent genetic findings identified the hypothalamus as an
important regulator of appetite, food intake and energy expenditure. Over the past 10 years …

Over the past two centuries, prevalent models of energy and glucose homeostasis have
emerged from careful anatomical descriptions in tandem with an understanding of cellular …

With the still‐growing prevalence of obesity worldwide, major efforts are made to understand
the various behavioral, environmental, and genetic factors that promote excess fat gain …