Meiotic Arrest in Human Oocytes Is Maintained by a Gs Signaling Pathway

A DiLuigi, VN Weitzman, MC Pace… - Biology of …, 2008 - academic.oup.com
In mammalian oocytes, the maintenance of meiotic prophase I arrest prior to the surge of LH
that stimulates meiotic maturation depends on a high level of cAMP within the oocyte. In …

[HTML][HTML] A Gs-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-Gs …

RP Norris, L Freudzon, M Freudzon, AR Hand… - Developmental …, 2007 - Elsevier
The maintenance of meiotic prophase arrest in fully grown vertebrate oocytes depends on
the activity of a Gs G-protein that activates adenylyl cyclase and elevates cAMP, and in the …

[HTML][HTML] The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes

M Hinckley, S Vaccari, K Horner, R Chen, M Conti - Developmental biology, 2005 - Elsevier
In mammalian and amphibian oocytes, the meiotic arrest at the G2/M transition is dependent
on cAMP regulation. Because genetic inactivation of a phosphodiesterase expressed in …

[HTML][HTML] Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes

LM Mehlmann - Developmental biology, 2005 - Elsevier
The maintenance of meiotic prophase arrest in mouse oocytes within fully grown follicles,
prior to the surge of luteinizing hormone (LH) that triggers meiotic resumption, depends on a …

cAMP pulsing of denuded mouse oocytes increases meiotic resumption via activation of AMP-activated protein kinase

J Chen, MM Chi, KH Moley, SM Downs - Reproduction, 2009 - rep.bioscientifica.com
Fully-grown mammalian oocytes within healthy preovulatory follicles are arrested in the first
meiotic prophase until the gonadotropins surge in vivo. However, the means by which …

The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X …

J Deng, S Lang, C Wylie… - Molecular endocrinology, 2008 - academic.oup.com
Oocytes are held in meiotic arrest in prophase I until ovulation, when gonadotropins trigger a
subpopulation of oocytes to resume meiosis in a process termed “maturation.” Meiotic arrest …

Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein

L Freudzon, RP Norris, AR Hand, S Tanaka… - The Journal of cell …, 2005 - rupress.org
The arrest of meiotic prophase in mouse oocytes within antral follicles requires the G protein
Gs and an orphan member of the G protein–coupled receptor family, GPR3. To determine …

[HTML][HTML] Maintenance of meiotic prophase arrest in vertebrate oocytes by a Gs protein-mediated pathway

RR Kalinowski, CH Berlot, TLZ Jones, LF Ross… - Developmental …, 2004 - Elsevier
Maintenance of meiotic prophase arrest in fully grown vertebrate oocytes depends on an
elevated level of cAMP in the oocyte. To investigate how the cAMP level is regulated, we …

Stops and starts in mammalian oocytes: recent advances in understanding the regulation of meiotic arrest and oocyte maturation

LM Mehlmann - Reproduction, 2005 - rep.bioscientifica.com
Mammalian oocytes grow and undergo meiosis within ovarian follicles. Oocytes are arrested
at the first meiotic prophase, held in meiotic arrest by the surrounding follicle cells until a …

Premature ovarian aging in mice deficient for Gpr3

C Ledent, I Demeestere, D Blum… - Proceedings of the …, 2005 - National Acad Sciences
After becoming competent for resuming meiosis, fully developed mammalian oocytes are
maintained arrested in prophase I until ovulation is triggered by the luteotropin surge …