Aim: To investigate the distribution of cation channel of sperm 1 (CATSPER1) protein and
the presence of CATSPER1 mRNA in human testis and ejaculated spermatozoa. The …

CatSper is a unique sperm cation channel-like protein family exclusively expressed in the
testis and plays important roles in sperm functions. The temporal expression profiles of …

OBJECTIVE: To explore the contraceptive potential of the CatSper1 transmembrane
domains and pore region in vitro. DESIGN: In vitro study with human sperm and mouse …

PURPOSE: We aimed to elucidate the expression and intracellular localization of sperm-
specific cation channel CatSper in human spermatozoa. Moreover, the relationship between …

Abstract STUDY QUESTION Is CatSper1 expression in human spermatozoa related to
semen parameter values and sperm functions? SUMMARY ANSWER CatSper1 expression …

OBJECTIVE: To evaluate the contraceptive ability of two B-cell epitopes in CatSper1.
DESIGN: In vivo study with mice. SETTING: University laboratory animal service center …

BACKGROUND: The search for Ca2+ channels residing in sperm has led to the recent
cloning and characterization of a novel gene, named CatSper, which codes for a unique …

STUDY QUESTION Are genetic abnormalities in CATSPER (cation channel of sperm) genes
associated with idiopathic male infertility with normal semen parameters and, if so, how do …

The cation channel of sperm (CatSper) protein family plays important roles in male
reproduction and infertility. The four members of this family are expressed exclusively in the …

Interest in ion channels as drug targets for contraception has grown with the realization that
certain ion channel subunits are located exclusively in sperm. Selective knockdown of ion …