Previous studies have shown that microglia impact the proliferation and differentiation of
neurons during hippocampal neurogenesis via the fractalkine/CX3 chemokine receptor 1 …

Microglial cells participate in brain development and influence neuronal loss and synaptic
maturation. Fractalkine is an important neuronal chemokine whose expression increases …

In adult brain, the chemokine CXCL12 and its receptors CXCR4 and CXCR7 are expressed
in neural progenitor and glial cells. Conditional Cxcl12 or Cxcr4 gene knockout in mice …

In the developing brain, microglial cells play an important role in shaping neuronal circuits.
These immune cells communicate with neurons through fractalkine (CX3CL1), a neuronal …

Several cytokines and chemokines are now known to play normal physiological roles in the
brain where they act as key regulators of communication between neurons, glia, and …

Accumulative evidence indicates that microglial cells influence the normal development of
brain synapses. Yet, the mechanisms by which these immune cells target maturating …

In recent years several evidence demonstrated that some features of hippocampal biology,
like neurogenesis, synaptic transmission, learning, and memory performances are deeply …

Microglial cells are the resident macrophages of the central nervous system (CNS). Besides
their classical roles in pathological conditions, these immune cells also dynamically interact …

Deficient neuron–microglia signaling during brain development is associated with abnormal
synaptic maturation. However, the precise impact of deficient microglia function on synaptic …

We investigated the role of the CXCR4 chemokine receptor in development of the mouse
hippocampus. CXCR4 mRNA is expressed at sites of neuronal and progenitor cell migration …