Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) enzyme, as a sensor of DNA damage,
could convert nicotinamide adenine dinucleotide (NAD) into long poly (ADP-ribose) chains …

Abstract Type 2 diabetes mellitus (DM2) follows impaired glucose tolerance in obesity and is
frequently associated with hypertension, causing adverse myocardial remodelling and …

Poly (ADP-ribosyl) ation catalyzed by the poly (ADP-ribose) polymerases (PARPs) is an
immediate post-translational modification of proteins with a homopolymeric chain of …

Diabetic cardiomyopathy (DCM) is characterized by structural alterations such as
cardiomyocyte hypertrophy, necrosis and focal fibrosis. Poly (ADP-ribose) polymerase 1 …

Abstract We previously identified AG-690/11026014 (6014) as a novel poly (ADP-ribose)
polymerase-1 (PARP-1) inhibitor that effectively prevented angiotensin II (Ang II)-induced …

Overactivation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) contributes to
the development of cell dysfunction and tissue injury in various pathophysiological …

Poly (ADP-ribose) polymerase-1 (PARP), a chromatin-bound enzyme, is activated by cell
oxidative stress. Because oxidative stress is also considered a main component of …

Abstract Poly (ADP-ribose) polymerase (PARP) activation has been implicated in the
pathogenesis of acute and chronic myocardial dysfunction and heart failure. The goal of the …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in regulating genome
stability, cell cycle progression, and cell survival. However, overactivation of PARP has been …

Myocardial infarction causes cardiomyocyte loss, and depleted cardiomyocyte proliferative
capacity after birth impinges the heart repair process, eventually leading to heart failure. This …