N-terminal propeptide of type II collagen (PIINP) is a biomarker reflecting cartilage formation.
PIINP exists in two main splice variants termed as type IIA and type IIB collagen NH2 …

The aim of this study was to enable measurement of cartilage formation by a novel
biomarker of type II collagen formation. The competitive enzyme-linked immunosorbent …

OBJECTIVE: Progression of joint damage in osteoarthritis (OA) is likely to result from an
imbalance between cartilage degradation and synthesis processes. Markers reflecting these …

Type II collagen, the most abundant protein of cartilage matrix, is synthesized as a
procollagen molecule including the N-(PIINP) and C-(PIICP) propeptides at each end. Type …

Procollagen type I carboxy-terminal propeptide (PICP), derived from type I procollagen, has
been identified as an indicator of type I collagen synthesis in bone matrix formation and skin …

Background Cartilage destruction in osteoarthritis (OA) involves excessive degradation and
increased synthesis of cartilage matrix macromolecules including type II collagen and …

Objective Cartilage homeostasis relies on a balance of catabolism and anabolism of
cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and …

Osteoarthritis (OA) is characterized by progressive degeneration of cartilage, formation of
cartilage at the cartilage edge, and remodeling of the subchondral bone. Pro-inflammatory …

OBJECTIVE: To investigate whether type II collagen turnover markers used for osteoarthritis
(OA) activity evaluation in body fluids can be detected at the level of specific histological …

C-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker
of cartilage degradation in human rheumatic diseases, if measured in synovial fluid or urine …