Evidence suggests a link between opioid use and kidney disease. This review summarizes
the known renal manifestations of opioid use including its role in acute and chronic kidney …

Opioids, both endogenous and exogenous, have a strong influence on the renal function
through different mechanisms, producing changes in the renal excretion of water and …

Pain in patients with impaired renal function may be a significant problem requiring
treatment with opioids. However, pharmacokinetic and metabolic changes associated with …

In patients suffering from moderate-to-severe chronic kidney disease (CKD) or end-stage
renal disease (ESRD), subjected to hemodialysis (HD), pain is very common, but often …

Background/Aims: The etiology of renal dysfunction in cancer patients is likely to be
multifactorial. A large proportion of these patients receive opioid analgesics, but whether …

Objectives. To investigate the prevalence of chronic pain and opioid management among
patients with chronic kidney disease (CKD). Design. Systematic review. Methods. A …

1. Over the past 50 years considerable evidence has been reported suggesting that
endogenous opioids participate in the control of renal function. 2. Exogenous administration …

The use of opioid analgesics in renal dysfunction is potentially problematic and many
patients with end stage renal disease are unable to tolerate these medications. A greater …

Background Methadone is commonly administered for chronic pain relief and treatment of
opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have …

Background Renal impairment and the risk of toxicity caused by accumulation of opioids
and/or active metabolites is an under‐investigated issue. This study aimed at analysing if …