Coumarins and coumarin-related compounds in pharmacotherapy of cancer

E Küpeli Akkol, Y Genç, B Karpuz, E Sobarzo-Sánchez… - Cancers, 2020 - mdpi.com
Cancer is one of the most common causes of disease-related deaths worldwide. Despite the
discovery of many chemotherapeutic drugs that inhibit uncontrolled cell division processes …

Current developments of coumarin-based anti-cancer agents in medicinal chemistry

S Emami, S Dadashpour - European Journal of Medicinal Chemistry, 2015 - Elsevier
Cancer is one of the leading health hazards and the prominent cause of death in the world.
A number of anticancer agents are currently in clinical practice and used for treatment of …

Coumarin: a promising scaffold for anticancer agents

M Kaur, S Kohli, S Sandhu, Y Bansal… - Anti-Cancer Agents in …, 2015 - ingentaconnect.com
Coumarin enjoys an important place in drug discovery process due to its presence in
diversity of biologically active compounds. Many compounds of plant origin are derivatives …

Recent developments of C-4 substituted coumarin derivatives as anticancer agents

J Dandriyal, R Singla, M Kumar, V Jaitak - European journal of medicinal …, 2016 - Elsevier
Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in
clinical practice are having a high prevalence of side effect and multidrug resistance …

Anticancer potential of coumarin and its derivatives

N Bhattarai, AA Kumbhar, YR Pokharel… - Mini Reviews in …, 2021 - ingentaconnect.com
Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of
cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different …

A review on chemical profile of coumarins and their therapeutic role in the treatment of cancer

K Venkata Sairam, BM Gurupadayya… - Current Drug …, 2016 - ingentaconnect.com
Coumarin class of organic compounds consists of 1, 2-benzopyrone ring system as a basic
parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and …

Anticancer activity of natural coumarins for biological targets

A Önder - Studies in Natural Products Chemistry, 2020 - Elsevier
Coumarins are a class of secondary metabolites and naturally occurring benzopyrone
derivatives. Previously, the identification of natural coumarins from natural sources has been …

Coumarins: old compounds with novel promising therapeutic perspectives

ME Riveiro, N De Kimpe, A Moglioni… - Current medicinal …, 2010 - ingentaconnect.com
Natural as well as synthetic coumarins have recently drawn much attention due to its broad
pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti …

Coumarin derivatives with anticancer activities: An update

XF Song, J Fan, L Liu, XF Liu, F Gao - Archiv der Pharmazie, 2020 - Wiley Online Library
Cancer can invade or spread to almost all parts of the body. The increasing morbidity and
high mortality of cancer create a great demand for the development of novel anticancer …

Recent advancements of coumarin-based anticancer agents: An up-to-date review

T Al-Warhi, A Sabt, EB Elkaeed, WM Eldehna - Bioorganic Chemistry, 2020 - Elsevier
Heading the list of the critical health-related issues worldwide, cancer continues to be a one
of the most serious life-threatening diseases. The rate of cancer-related mortality is at …