Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese

Z Zhou, Z Li, C Wang, X Li, X Cheng, C Li, Y Shi - Hereditas, 2019 - Springer
Background Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with
relatively high heritability. This study aims to identify whether a candidate gene, SLC28A2 …

Genetic Association Between SLC22A12 Variants and Susceptibility to Hyperuricemia: A Meta-Analysis

Q Zhen, W Keliang, Q Hongtao… - Genetic Testing and …, 2022 - liebertpub.com
Aims: Gout is a form of inflammatory arthritis characterized by the deposition of monosodium
urate crystals. An important risk factor for gout is hyperuricemia. The relationship between …

Association of an intronic SNP of SLC2A9 gene with serum uric acid levels in the Chinese male Han population by high-resolution melting method

M Guan, D Zhou, W Ma, Y Chen, J Zhang, H Zou - Clinical rheumatology, 2011 - Springer
SLC2A9 is a novel identified urate transporter influencing uric acid metabolism. It has been
suggested that the single-nucleotide polymorphisms in SLC2A9 may affect the serum UA …

Polymorphisms in the presumptive promoter region of the SLC2A9 gene are associated with gout in a Chinese male population

C Li, N Chu, B Wang, J Wang, J Luan, L Han, D Meng… - PloS one, 2012 - journals.plos.org
Background Glucose transporter 9 (GLUT9) is a high-capacity/low-affinity urate transporter.
To date, several recent genome-wide association studies (GWAS) and follow-up studies …

Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case–control study

ZW Zhou, LL Cui, L Han, C Wang, ZJ Song… - BMC medical …, 2015 - Springer
Background Gout is a common arthritic disease resulting from elevated serum uric acid
(SUA) level. A large meta-analysis including 28,141 individuals identified nine single …

Polymorphism rs3733591 of the SLC2A9 gene and metabolic syndrome affect gout risk in Taiwan Biobank subjects

CN Lin, CC Ho, PC Hsieh, CH Hsiao, ON Nfor… - Frontiers in …, 2024 - frontiersin.org
Background: Over the past few decades, gout and diseases like metabolic syndrome (MetS)
have become more prevalent. Attempts have been made in Taiwan to identify the genes …

[PDF][PDF] The role of SLC2A9 variants in hyperuricemia and gout

AJ Chisnall - 2014 - ourarchive.otago.ac.nz
Gout is a debilitating arthritis caused by elevated levels of serum urate in the blood
(hyperuricemia). The prevalence of gout is on the rise worldwide with particularly high rates …

Whole‐Exome Sequencing Reveals a Rare Missense Variant in SLC16A9 in a Pedigree with Early‐Onset Gout

XF Huang, L Sun, C Zhang, Z Zhou… - BioMed research …, 2020 - Wiley Online Library
Gout is a common inflammatory arthritis triggered by monosodium urate deposition after
longstanding hyperuricemia. In the general community, the disease is largely polygenic in …

Effects of multiple genetic loci on the pathogenesis from serum urate to gout

Z Dong, J Zhou, S Jiang, Y Li, D Zhao, C Yang, Y Ma… - Scientific Reports, 2017 - nature.com
Gout is a common arthritis resulting from increased serum urate, and many loci have been
identified that are associated with serum urate and gout. However, their influence on the …

Genetic analysis for rs2280205 (A> G) and rs2276961 (T> C) in SLC2A9 polymorphism for the susceptibility of gout in Cameroonians: a pilot study

JR Nkeck, M Singwé Ngandeu, V Ama Moor… - BMC research …, 2018 - Springer
Objective To determine the association of non-synonymous variants rs2280205 and
rs2276961 of the SLC2A9 gene to gout in Cameroonians. Results In a case–control study …