We examined the hypothesis that injurious ventilatory strategies (large tidal volume [Vt]
and/or low positive end-expiratory pressure [PEEP]) would increase release of inflammatory …

ContextStudies have shown that an inflammatory response may be elicited by mechanical
ventilation used for recruitment or derecruitment of collapsed lung units or to overdistend …

Mechanical ventilation is an often life-saving treatment which unfortunately is not devoid of
risk. In recent years, extensive research has called the attention of physicians to the …

Patients with acute respiratory distress syndrome are at increased risk for developing
multiorgan system dysfunction. The goal of this study was to establish an in vivo murine …

We investigated the production of proinflammatory cytokines by the lung during high
mechanical stretch in vivo. To do this, we subjected rats to high-volume (42 ml/kg tidal …

Recent clinical trials have shown that the survival of patients with acute respiratory distress
syndrome (ARDS) is improved by ventilation with reduced volumes. These studies …

Background Mechanical ventilation with high tidal volumes (V (T)) in contrast to mechanical
ventilation with low V (T) has been shown to increase plasma levels of proinflammatory and …

We examined the effect of ventilation strategy on lung inflammatory mediators in the
presence and absence of a preexisting inflammatory stimulus. 55 Sprague-Dawley rats were …

Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their
relative contribution to inflammation in ventilator-induced lung injury is not well established …

Previous animal studies have identified a role for activation of innate immunity in the
pathogenesis of ventilator-associated lung injury. These studies have used large tidal …