Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly (butylcyanoacrylate) nanoparticles

C Melguizo, L Cabeza, J Prados, R Ortiz… - Drug design …, 2015 - Taylor & Francis
Doxorubicin (Dox) is widely used for the combined chemotherapy of solid tumors. However,
the use of these drug associations in lung cancer has low antitumor efficacy. To improve its …

Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly (butylcyanoacrylate) nanoparticles

L Cabeza, R Ortiz, JL Arias, J Prados… - International journal …, 2015 - Taylor & Francis
The use of doxorubicin (DOX), one of the most effective antitumor molecules in the treatment
of metastatic breast cancer, is limited by its low tumor selectivity and its severe side effects …

Improved antitumor activity and reduced toxicity of doxorubicin encapsulated in poly (ε-caprolactone) nanoparticles in lung and breast cancer treatment: An in vitro and …

L Cabeza, R Ortiz, J Prados, ÁV Delgado… - European Journal of …, 2017 - Elsevier
Abstract Poly (ε-caprolactone)(PCL) nanoparticles (NPs) offer many possibilities for drug
transport because of their good physicochemical properties and biocompatibility …

Enhanced anti-tumor effects of doxorubicin on glioma by entrapping in polybutylcyanoacrylate nanoparticles

Y Zhang, J Yu, L Zhang, J Cai, D Cai, C Lv - Tumor Biology, 2016 - Springer
For effective therapy for glioma, it is essential for chemotherapeutics to pass the blood-brain
barrier to target glioma cells with little side effects to surrounding normal cells. In this study …

Cisplatin-loaded polybutylcyanoacrylate nanoparticles with improved properties as an anticancer agent

SE Alavi, S Muflih Al Harthi… - International Journal of …, 2019 - mdpi.com
This study aims to improve the cytotoxicity and potency of cisplatin-loaded
polybutylcyanoacrylate (PBCA) nanoparticles (NPs) for the treatment of lung cancer through …

Enhanced tumour uptake of doxorubicin loaded poly (butyl cyanoacrylate) nanoparticles in mice bearing Dalton's lymphoma tumour

LH Reddy, RK Sharma, RSR Murthy - Journal of drug targeting, 2004 - Taylor & Francis
The objective of this study is to enhance the delivery of Doxorubicin hydrochloride to
Dalton's lymphoma solid tumour through poly (butyl cyanoacrylate)(PBC) nanoparticles …

HPLC quantification of doxorubicin in plasma and tissues of rats treated with doxorubicin loaded poly (alkylcyanoacrylate) nanoparticles

K Alhareth, C Vauthier, C Gueutin, G Ponchel… - … of Chromatography B, 2012 - Elsevier
The long-term clinical use of doxorubicin (Dox), one of the most important anticancer agent
in use, is limited by dose-related acute cardiotoxicity, myelo-suppression and multidrug …

Covalently coupling doxorubicin to polymeric nanoparticles as potential inhaler therapy: in vitro studies

G Ak - Pharmaceutical Development and Technology, 2021 - Taylor & Francis
Lung cancer is the most commonly diagnosed type of cancer worldwide, non-small cell lung
cancer accounts for most lung cancers. Doxorubicin is a widely used chemotherapy agent in …

Self-assembling doxorubicin prodrug forming nanoparticles for cancer chemotherapy: synthesis and anticancer study in vitro and in vivo

P Gou, W Liu, W Mao, J Tang, Y Shen… - Journal of Materials …, 2013 - pubs.rsc.org
The clinical utility of doxorubicin (DOX) is restricted by its severe side effects. Continuous
efforts are aimed at developing efficacious DOX-delivery systems that may overcome the …

Dual-sensitive and biodegradable core-crosslinked HPMA copolymer–doxorubicin conjugate-based nanoparticles for cancer therapy

M Tang, M Zhou, Y Huang, J Zhong, Z Zhou… - Polymer Chemistry, 2017 - pubs.rsc.org
In this study, to increase the blood stability and circulation time of polymeric nanoparticles as
well as to investigate the effects of the structure on therapeutic indexes, 2 types of N-(2 …