Animal models of human drug abuse measuring (i) cocaine-seeking behavior maintained by
primary or secondary reinforcers,(ii) the time to extinction of cocaine-seeking behavior, and …

Frequency of drug access greatly affects the pattern and stability of cocaine self-
administration. Previous research has shown that restricted drug availability produces …

Rationale Recent evidence suggests that prolonged cocaine self-administration produces
escalation in drug-seeking behavior in rats analogous to the increased intake patterns …

Environmental stimuli that set the occasion wherein drugs are acquired can “trigger” drug‐
related behavior. Investigating the stimulus control of drug self‐administration in laboratory …

The purpose of the present study was to examine whether a history of responding under
food reinforcement schedules that generated either high or low response rates would …

The purpose of the present study was to examine whether a history of responding under
schedules that generate either high or low response rates could modify previously …

Rats allowed extended daily access (6 h) to cocaine, consume high doses of the drug and
escalate their cocaine intake over days, resembling the pattern of cocaine use seen in …

Rats were trained to respond with intravenous cocaine as the reinforcer under a fixed
interval 15-min schedule, during which conditioned stimuli paired with cocaine were …

Rationale Behavioral procedures that incorporate dynamic changes in drug-maintained
behavior are needed to model the development of cocaine addiction in humans. Objectives …

Cocaine self-administration provides a methodology allowing researchers to study changes
in distinct aspects of drug-taking behavior that model behaviors observed in drug addicts …