Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the cellular
level alternans is observed as beat-to-beat alternations in contraction, action potential (AP) …

Key points Cardiac alternans–periodic beat‐to‐beat alternations in contraction, action
potential (AP) morphology or cytosolic calcium transient (CaT) amplitude–is a high risk …

Key points Cardiac alternans refers to a beat‐to‐beat alternation in contraction, action
potential (AP) morphology and Ca2+ transient (CaT) amplitude, and represents a risk factor …

Rationale: Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the
cellular level alternans manifests as beat-to-beat alternations in contraction, action potential …

Cardiac alternans is defined as beat‐to‐beat alternations in contraction strength, action
potential duration (APD), and Ca transient (CaT) amplitude. Cardiac excitation–contraction …

Cardiac alternans is a recognized risk factor for cardiac arrhythmia and sudden cardiac
death. At the cellular level, Ca2+ alternans appears as cytosolic Ca2+ transients of …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, but our knowledge of the
arrhythmogenic substrate is incomplete. Alternans, the beat-to-beat alternation in the shape …

Ca2+ alternans is a potentially arrhythmogenic beat‐to‐beat alternation of the amplitude of
the action potential‐induced [Ca2+] i transient in cardiac myocytes. Despite its …

Electrocardiographic alternans is known to predispose to increased susceptibility to life
threatening arrhythmias and sudden cardiac death. While this decreased level of cardiac …

Key points A mathematical model of a small conductance Ca2+‐activated potassium (SK)
channel was developed and incorporated into a physiologically detailed ventricular myocyte …