Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Background: Herbal products have grown steadily across the globe and have increasingly
been incorporated into western medicine for healthcare aims, thereby causing potential …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …

Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester-and amide-containing compounds. CESs dominate both the biotransformation of …

Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is
capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and …

A series of studies were designed and carried out in order to explore the potential for the
major human hepatic hydrolase, carboxylesterase 1 (hCES1), to serve as a target of …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Abstract Human carboxylesterase 2A (hCES2A) is a key serine hydrolase responsible for
the metabolic clearance of large number of compounds bearing the ester-or amide-bond (s) …