Introduction: Carboxylesterases play major roles in the hydrolysis of numerous
therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety …

Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …

The aims of this study were to develop a robust method for simultaneous quantification of
carboxylesterases (CESs) 1 and 2 and to quantify those absolute protein levels in human …

Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity
triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this …

Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Excipients …

Human carboxylesterase 1A1 (hCES1A) is a promising target for the treatment of
hyperlipidemia and obesity-associated metabolic diseases. To date, the highly specific and …

The dose-limiting toxicity of the highly effective anticancer agent 7-ethyl-10-[4-(1-piperidino)-
1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is delayed diarrhea. This is …

Abstract The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several
enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate …

Carboxylesterase (CES) is important for detoxification of a wide range of drugs and
xenobiotics and catalyzes cholesterol and fatty acid metabolism. Cynomolgus macaques are …

The human carboxylesterase 1 (CES1), responsible for the biotransformation of many
diverse therapeutic agents, may contribute to the occurrence of adverse drug reactions and …