Carboxylesterase (CES) is important for detoxification of a wide range of drugs and
xenobiotics and catalyzes cholesterol and fatty acid metabolism. Cynomolgus macaques are …

The human carboxylesterase 1 (CES1), responsible for the biotransformation of many
diverse therapeutic agents, may contribute to the occurrence of adverse drug reactions and …

Carboxylesterases (CE) are ubiquitous enzymes thought to be responsible for the
metabolism and detoxification of xenobiotics. Numerous clinically used drugs including …

Abstract Background and Objective Human carboxylesterase-1 (CES1) and human
carboxylesterase-2 (CES2) play an important role in metabolizing many medications …

Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …

Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism
and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of …

Pyrethroids are broad-spectrum insecticides that widely used in many countries, while
humans may be exposed to these toxins by drinking or eating pesticide-contaminated foods …

Mammalian carboxylesterases (CESs) are essential members of serine esterase hydrolase
superfamily, which are widely distributed in many tissues including liver, intestine, lung and …

Carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and
exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid …

Carboxylesterases are essential enzymes in the hydrolysis and detoxification of numerous
pharmaceuticals and pesticides. They are vital in mediating organophosphate toxicity and in …