Human carboxylesterase 1 (hCE1) exhibits broad substrate specificity and is involved in
xenobiotic processing and endobiotic metabolism. We present and analyze crystal …

Background: Carboxylesterases (CEs) are ubiquitous enzymes responsible for the
hydrolysis of numerous clinically useful drugs. As ester moieties are frequently included in …

Carboxylesterases (CEs) are important enzymes that catalyze biological detoxification,
hydrolysis of certain pesticides, and metabolism of many esterified drugs. The development …

Carboxylesterases (CES) metabolize esters. Two CES isoforms are expressed in human
liver (CES1 and CES2) and liver extracts are used in reaction phenotyping studies to discern …

In vitro inhibition studies on drug-metabolizing enzyme activity are useful for understanding
drug-drug interactions and for drug development. However, the profile of the inhibitory …

Human carboxylesterase (CES) 1A is responsible for the biotransformation of angiotensin-
converting enzyme (ACE) inhibitors such as imidapril and temocapril. Because antidiabetic …

Abstract Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the
human intestine and various tumour tissues, plays important roles in the oral bioavailability …

Several mouse carboxylesterase (CES) isozymes have been identified, but information
about their roles in drug metabolism is limited. In this study, we purified and characterized a …

Phthalate esters (PAEs), accompanied by phthalate monoesters as hydrolysis metabolites in
humans, have been widely used as plasticizers and exhibited disruptive effects on the …

Human carboxylesterase (CES) 1A and CES2, two major forms of human CES, dominate the
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11) …