Carboxylesterase (CES) 1 and CES2 are two major hepatic hydrolases responsible for the
metabolism of numerous endogenous and exogenous compounds. In this study, age-and …

Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing
xenobiotics, including complex molecules, such as the anticancer drugs irinotecan (CPT-11) …

Fructus psoraleae (FP) is the dried ripe seeds of Psoralea corylifolia L.(Fabaceae) widely
used in Asia, and has been reported to exert important biochemical and pharmacological …

In clinical practice, a large number of prodrugs and active drugs containing an ester,
carbamate or amide moiety are used. Carboxylesterase (CaE, EC 3.1. 1.1) is the key …

Abstract Carboxylesterase 1 (CES1), one of the most abundant serine hydrolases in
mammals, has drawn much attentions in recent years, owing to this enzyme involves in …

The cynomolgus monkey is a nonhuman primate that is often used for pharmacokinetic and
toxicokinetic studies of new chemical entities. Species differences in drug metabolism are …

Magnolol, the most abundant bioactive constituent of the Chinese herb Magnolia officinalis,
has been found with multiple biological activities, including anti-oxidative, anti-inflammatory …

Carboxylesterases hydrolyze chemicals containing such functional groups as a carboxylic
acid ester, amide and thioester. The liver contains the highest carboxylesterase activity and …

Carboxylesterase 1 (CES1) is the major hepatic hydrolytic enzyme responsible for the
metabolism of many therapeutic agents, toxins, and endogenous compounds existing as …

Members of the carboxylesterase 2 (Ces2/CES2) family have been studied intensively with
respect to their hydrolytic function on (pro) drugs, whereas their physiological role in lipid …