In a continuing search for potential inhibitors against human carboxylesterases 1A1 and 2A1
(hCES1A1 and hCES2A1), an EtOAc extract of the roots of Paeonia lactiflora showed strong …

Hydrolytic reactions constitute an important pathway of drug metabolism and a significant
route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that …

Carboxylesterases (CES) are a well recognized, yet incompletely characterized family of
proteins that catalyze neutral lipid hydrolysis. Some CES have well-defined roles in …

In this review, novel aspects of the role of esterases, which contribute to the metabolism of
10% of therapeutic drugs, are described. Esterases hydrolyze the compounds that contain …

Background Human carboxylesterases (hCES) are key serine hydrolases responsible for
the hydrolysis of a wide range of endogenous and xenobiotic esters. Although it has been …

The present clinical trial investigated the impact of selected SNPs in CES1 on the metabolic
activity of the enzyme. For this purpose, we used methylphenidate (MPH) as a …

At least five families of mammalian carboxylesterases (CES) catalyse the hydrolysis or
transesterification of a wide range of drugs and xenobiotics and may also participate in fatty …

The carboxylesterase drug hydrolysis pathway has been used extensively to improve the
oral availability of drugs under the assumption that the high capacity and low substrate …

The human carboxylesterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a
serine esterase governing both metabolic deactivation and activation of numerous …

Soluble epoxide hydrolase (sEH) is an enzyme that contributes importantly to metabolism of
endogenous, biologically active arachidonic acid derived epoxyeicosatrienoic acids …