Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are the major hydrolytic
enzymes responsible for the metabolism of numerous therapeutic agents as well as …

Hydrolytic reactions constitute an important pathway of drug metabolism and a significant
route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that …

In a continuing search for potential inhibitors against human carboxylesterases 1A1 and 2A1
(hCES1A1 and hCES2A1), an EtOAc extract of the roots of Paeonia lactiflora showed strong …

Abstract Human carboxylesterases 1 (hCE1), one of the most important human drug
metabolizing enzymes, catalyzes the hydrolysis of a large number of structurally diverse of …

Human carboxylesterase 1 (hCE1), plays pivotal roles in endobiotics homeostasis and
xenobiotic metabolism. The plasma level of hCE1 could serve as a useful serologic …

Metabolic problems lead to numerous failures during clinical trials, and much effort is now
devoted in developing in silico models predicting metabolic stability and metabolites. Such …

Carboxylesterases hydrolyze a large array of endogenous and exogenous ester-containing
compounds, including pyrethroid insecticides. Herein, we report the specific activities and …

Carboxylesterases (CES) are a well recognized, yet incompletely characterized family of
proteins that catalyze neutral lipid hydrolysis. Some CES have well-defined roles in …

In this review, novel aspects of the role of esterases, which contribute to the metabolism of
10% of therapeutic drugs, are described. Esterases hydrolyze the compounds that contain …

Background Human carboxylesterases (hCES) are key serine hydrolases responsible for
the hydrolysis of a wide range of endogenous and xenobiotic esters. Although it has been …