Summary The Interleukin 1 (IL‐1) family plays a central role in the generation and regulation
of inflammatory responses, in both innate and adaptive immunity. Although the IL‐1 …

The cytokine interleukin–1 (IL–1) plays a key role in the pathogenesis of inflammatory and
immune diseases. Several disease—genotype association studies have addressed the …

Cytokines, signaling proteins produced by a variety of cell types, are essential for the
development and functioning of both innate and adaptive immune response. Cytokine gene …

Interleukins (ILs)—which are important members of cytokines—consist of a vast group of
molecules, including a wide range of immune mediators that contribute to the immunological …

Cytokine (receptor) genes have traditionally attracted great interest as plausible genetic risk
factors for autoimmune disease. Since 2007, the implementation of genome-wide …

More than any other family, the IL-1 Family of 11 cytokines and 10 receptors provides the
host with an endogenous innate immune system, whereas the family of Toll-like Receptors …

Cytokines are proteins that regulate immune and inflammatory reactions as well as
haematopoiesis. This group of molecules is very heterogeneous including, for example …

Abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-and anti-inflammatory
properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood …

Interleukin 1 receptor-like 1 (IL1RL1) is gaining in recognition due to its involvement in
immune/inflammatory disorders. Well-designed animal studies have shown its critical role in …

Abstract Interleukin-1-receptor antagonist (IL-1RA) modulates the biological activity of the
proinflammatory cytokine interleukin-1 (IL-1) and could play an important role in the …