Interleukin 1 gene polymorphism and susceptibility to disease
K Khazim, EE Azulay, B Kristal… - Immunological reviews, 2018 - Wiley Online Library
Summary The Interleukin 1 (IL‐1) family plays a central role in the generation and regulation
of inflammatory responses, in both innate and adaptive immunity. Although the IL‐1 …
of inflammatory responses, in both innate and adaptive immunity. Although the IL‐1 …
Five novel intragenic dimorphisms in the human interleukin–1 genes combine to high informativity
JF Guasch, RM Bertina, PH Reitsma - Cytokine, 1996 - Elsevier
The cytokine interleukin–1 (IL–1) plays a key role in the pathogenesis of inflammatory and
immune diseases. Several disease—genotype association studies have addressed the …
immune diseases. Several disease—genotype association studies have addressed the …
Cytokine and cytokine receptor gene polymorphisms and their functionality
AJP Smith, SE Humphries - Cytokine & growth factor reviews, 2009 - Elsevier
Cytokines, signaling proteins produced by a variety of cell types, are essential for the
development and functioning of both innate and adaptive immune response. Cytokine gene …
development and functioning of both innate and adaptive immune response. Cytokine gene …
The Interleukin‐1 (IL‐1) superfamily cytokines and their single nucleotide polymorphisms (SNPs)
Interleukins (ILs)—which are important members of cytokines—consist of a vast group of
molecules, including a wide range of immune mediators that contribute to the immunological …
molecules, including a wide range of immune mediators that contribute to the immunological …
Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies
K Vandenbroeck - Journal of Interferon & Cytokine Research, 2012 - liebertpub.com
Cytokine (receptor) genes have traditionally attracted great interest as plausible genetic risk
factors for autoimmune disease. Since 2007, the implementation of genome-wide …
factors for autoimmune disease. Since 2007, the implementation of genome-wide …
[HTML][HTML] Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity
CA Dinarello - Immunological reviews, 2018 - ncbi.nlm.nih.gov
More than any other family, the IL-1 Family of 11 cytokines and 10 receptors provides the
host with an endogenous innate immune system, whereas the family of Toll-like Receptors …
host with an endogenous innate immune system, whereas the family of Toll-like Receptors …
Gene polymorphisms of interleukins 1 and 10 in infectious and autoimmune diseases
M Hurme, N Lahdenpohja, S Santtila - Annals of medicine, 1998 - Taylor & Francis
Cytokines are proteins that regulate immune and inflammatory reactions as well as
haematopoiesis. This group of molecules is very heterogeneous including, for example …
haematopoiesis. This group of molecules is very heterogeneous including, for example …
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
TS Ahluwalia, BP Prins, M Abdollahi… - Human molecular …, 2021 - academic.oup.com
Abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-and anti-inflammatory
properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood …
properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood …
Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases
L Akhabir, A Sandford - Current genomics, 2010 - ingentaconnect.com
Interleukin 1 receptor-like 1 (IL1RL1) is gaining in recognition due to its involvement in
immune/inflammatory disorders. Well-designed animal studies have shown its critical role in …
immune/inflammatory disorders. Well-designed animal studies have shown its critical role in …
Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels
Abstract Interleukin-1-receptor antagonist (IL-1RA) modulates the biological activity of the
proinflammatory cytokine interleukin-1 (IL-1) and could play an important role in the …
proinflammatory cytokine interleukin-1 (IL-1) and could play an important role in the …