Aims: To determine the contribution of insulin signaling versus systemic metabolism to
metabolic and mitochondrial alterations in type 1 diabetic hearts and test the hypothesis that …

Background Pathophysiological processes underlying diabetic-related cardiomyopathies
are complex. Mitochondria dysfunction is often described as a cause of cardiac impairment …

Cardiac glucose uptake and oxidation are reduced in diabetes despite hyperglycemia.
Mitochondrial dysfunction contributes to heart failure in diabetes. It is unclear whether these …

People affected by diabetes are at an increased risk of developing heart failure than their
non-diabetic counterparts, attributed in part to a distinct cardiac pathology termed diabetic …

Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes
mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic …

Background—Obesity and diabetes mellitus are complex metabolic problems of pandemic
proportion, contributing to significant cardiovascular mortality. Recent studies have shown …

OBJECTIVE—Fatty acid–induced mitochondrial uncoupling and oxidative stress have been
proposed to reduce cardiac efficiency and contribute to cardiac dysfunction in type 2 …

Background—Diabetes-associated cardiac dysfunction is associated with mitochondrial
dysfunction and oxidative stress, which may contribute to left ventricular dysfunction. The …

Diabetes is recognized as an independent risk factor for cardiovascular morbidity and
mortality. This is due, in large part, to premature atherosclerosis, enhanced thrombogenicity …

Diabetes increases mortality and accelerates left ventricular (LV) dysfunction following
myocardial infarction (MI). This study sought to determine the impact of impaired myocardial …